11 Real World Data & Evidence Companies in 2026

Clinical trial data tells sponsors how a drug performs under controlled conditions. Real-world data — claims records, electronic health records, lab results, patient-reported outcomes collected outside a trial — tells them how it performs everywhere else. A real world data provider sources, links, and structures that data; a real world evidence vendor turns it into the analysis sponsors use for regulatory submissions, payer negotiations, and post-market safety monitoring.

The companies on this list offer real world data and evidence services, spanning claims and EHR data marketplaces, disease-specific registries, and AI-driven data curation. This is an unranked list — the order carries no judgment about quality or fit. Several also extend their real-world data work into clinical trial feasibility and recruitment support.

HealthVerity

HealthVerity Marketplace operates what it describes as the nation's largest interoperable healthcare and consumer data ecosystem, spanning more than 75 unique sources and reporting more than 330 million patients and 150 billion healthcare transactions. The company's identity resolution technology links de-identified patient records across claims, EHR, lab, pharmacy, and consumer data sources without exposing protected health information, and in 2025 it completed the acquisition of Symphony Health, a longitudinal pharmaceutical data and analytics provider divested by ICON plc. Based in Philadelphia, Pennsylvania, HealthVerity serves life sciences, insurance, and government clients building longitudinal patient journeys for research and regulatory work.

Datavant

Datavant operates a health data platform and network that enables more than 60 million healthcare records to move between organizations, connecting more than 70,000 hospitals and clinics and 75% of the 100 largest health systems in the US. The company's ecosystem includes more than 300 real-world data partners, positioning it as connective infrastructure between data holders and the researchers, payers, and life sciences companies who need linked datasets. Founded in 2017 and based in San Francisco, California, Datavant focuses on making healthcare data secure, accessible, and actionable across the broader healthcare ecosystem.

Flatiron Health

Flatiron Health describes itself as the pioneer in real-world evidence for oncology, partnering with hundreds of cancer centers and more than 20 top global developers of oncology therapeutics to turn cancer patient data into research-ready evidence. The company's technology and services support both patient care and research, working with regulators and researchers to generate evidence that complements traditional clinical trial data in cancer drug development. Founded in 2012 and based in New York, New York, Flatiron Health became an independent affiliate of the Roche Group in 2018.

OM1

OM1 combines real-world data with AI to drive precision health, offering RWD and Data Networks across specialty areas including immunology, mental health and neuroscience, cardiometabolic disease, dermatology, and gastroenterology. The company's ASPEN platform lets providers and researchers build custom data cohorts to measure and forecast patient outcomes, transforming population-level data into insights sponsors can act on. Founded in 2015, OM1 is based in Boston, Massachusetts.

Syapse

Syapse positions itself as a pioneering real-world evidence company focused specifically on cancer patients, transforming real-world data into insights that directly inform clinical care and forge active partnerships between healthcare organizations. The company's approach centers on comprehensive patient insights derived from advanced technologies applied to oncology-specific real-world data. Founded in 2008, Syapse is based in San Francisco, California.

PicnicHealth

PicnicHealth builds comprehensive electronic health records that give patients control over their own medical histories while generating real-world evidence datasets that researchers can use for studies. The company was founded by CEO Noga Leviner following her own experience navigating fragmented medical records as a Crohn's disease patient, shaping its patient-first approach to data collection. Founded in 2014, PicnicHealth is based in San Francisco, California.

Quinten Health

Quinten Health applies artificial intelligence and interpretable data science to healthcare, specializing in real-world data science services and real-world outcomes simulation built on more than a decade of underlying expertise. The company's work centers on predictive medicine and health outcomes simulation, using statistical modeling, pattern recognition, and virtual cohort simulations to support precision care decisions. Founded in 2021, Quinten Health is headquartered in Paris, France.

Akrivia Health

Akrivia Health emerged from the NHS and Oxford University to accelerate research in mental health and dementia, building what it describes as the largest repository of real-world data in neuroscience alongside an extensive clinico-genomic dataset. The company applies that data toward targeted interventions for conditions including bipolar disorder, schizophrenia, depression, and dementia. Founded in 2019, Akrivia Health is based in Oxford, England.

Pulse Infoframe

Pulse Infoframe has developed a real-world evidence platform supporting research in oncology, rare disease, and other complex conditions for more than a decade, collaborating with biopharmaceutical companies, research institutions, and patient advocacy groups. The company's cloud-based platform integrates and harmonizes novel data collected directly from sites and patients alongside existing registry and clinical trial data, supporting both research and regulatory submissions. Founded in 2011, Pulse Infoframe is based in London, Ontario, Canada.

Mendel.ai

Mendel transforms unstructured EMR data and clinical literature into analytics-ready data, combining machine learning with clinician review to unlock the potential of clinical data that structured fields alone would miss. The company's end-to-end approach positions unstructured data curation as the connective step between raw clinical records and usable real-world evidence. Founded in 2017, Mendel.ai is based in San Jose, California.

UBC

UBC partners with biopharmaceutical companies on patient support, safety, access, and value, offering evidence development solutions and late-stage research alongside its clinical trial management and decentralized study work. The company's evidence generation work sits within a broader portfolio spanning risk management and patient access, connecting specialty therapies to the patients who need them through collaborative, expert-driven programs. Founded in 2003, UBC is based in Blue Bell, Pennsylvania.

Explore the full real-world data landscape

The companies above represent a portion of a much larger field.

Diligent's platform includes over 365 Real World Data/Evidence Vendors, many with Vendor qualification data available on demand. Book a demo to explore Diligent's full vendor discovery database.

This article is intended as an informational overview of vendors operating in this space. Inclusion on this list does not constitute an endorsement, recommendation, or qualification by Diligent.