8 EHR-to-EDC Connector Apps for Clinical Trials in 2026

An EHR to EDC connector automates the transfer of patient data from a hospital or clinic's electronic health record system directly into a clinical trial's electronic data capture database, replacing the manual process of a site coordinator reading data off a medical record and retyping it into a separate research system. This kind of EHR-to-EDC connector app typically relies on interoperability standards like SMART on FHIR or HL7 to map structured fields such as labs and vital signs automatically, while newer AI-driven approaches are starting to extend that automation to unstructured data like physician notes.

The EHR-to-EDC connector apps below are listed in no particular order. Between them, these companies and providers cover direct EHR-to-EDC streaming and mapping tools, broader eSource platforms built to replace traditional EDC systems, healthcare interoperability infrastructure providers, and AI-driven tools for extracting trial-relevant data from unstructured clinical notes.

CareEvolution

CareEvolution operates MyDataHelps, a no-code digital health platform that lets researchers collect participant EHR data, claims data, wearable and sensor data, eConsent, and eCOA responses within a single FISMA-compliant system, alongside its HIEBus health information exchange technology used to convert data among HL7, C-CDA, and FHIR formats. Founded in 2004 in Ann Arbor, Michigan, the company brings more than 20 years of healthcare interoperability experience to studies spanning long COVID, mental health, and rare disease research. In 2025, CareEvolution launched enrollment through MyDataHelps for a CMV Transmission and Immune Tracking study run jointly with UMass Chan Medical School and Moderna, using a digital app to meet participants in childcare settings. The company also joined the Decentralized Trials & Research Alliance (DTRA) to support broader industry adoption of decentralized research methods.

Clinical Ink

Clinical Ink built its business around what it now calls the Lumenis eSource Ecosystem, a unified data platform designed to ingest clinical trial data from any source, including direct data capture, electronic clinical outcome assessments, and electronic patient-reported outcomes, into one system that supports both single-study and cross-study analytics. Founded in 2007 and based in Winston-Salem, North Carolina, the company added an eConsent module to Lumenis in 2020, following an EMA qualification opinion that endorsed the use of eSource direct data capture in clinical trials. CEO Ed Seguine has positioned Clinical Ink's platform as a direct alternative to traditional EDC systems, arguing that sponsors and CROs should treat EDC-only approaches as increasingly obsolete given the range of electronic data sources now available. The company focuses its therapeutic expertise on oncology, CNS, cardiometabolic, and rare disease trials, supporting sponsors directly and through a network of CRO partners.

Clinical Research IO (CRIO)

CRIO (Clinical Research IO) was built by a former clinical research site owner and became the first company to widely commercialize an eSource system for research sites, reaching more than 1,000 clinical research sites on its platform by 2022. Founded in Boston around 2015, the company's Central eSource platform lets sponsors and CROs create a single standardized data collection template centrally and publish it to every investigator site at once, rather than leaving each site to build its own. CRIO reports its platform delivers 40 percent higher enrollment, 40 percent faster study startup, and 40 percent fewer protocol deviations compared with paper-based processes, backed by a fully integrated CTMS, eRegulatory, and eConsent suite. The company has continued building toward direct EHR-to-EDC connectivity as an extension of its existing Reviewer eSource/EDC product, following its early moves into medical record API integration.

Datavant

Datavant operates a health data connectivity platform built around patient-level tokenization technology that lets organizations match and link records across different systems without exposing direct patient identifiers. The company, originally created within Roivant Sciences, merged with clinical data network Ciox Health in a $7 billion transaction in 2021, combining Datavant's tokenization technology with Ciox's clinical data exchange network to reach more than 80,000 hospitals and clinics. Datavant's technology is used in more than 270 clinical trials to tokenize data across Phase I and Phase II studies, enabling long-term follow-up and real-world evidence generation without exposing protected health information. The company reports enabling more than 60 million healthcare records to move between organizations annually, drawing on relationships with 75 percent of the 100 largest US health systems and more than 350 real-world data partners.

IgniteData

IgniteData built Archer, a cloud-based Virtual Research Assistant the company describes as the first scalable EHR-to-EDC solution capable of integrating with all major EHR and EDC systems on the market. Founded in Reading, England in 2014 and led by CEO Dan Hydes, the company ran a landmark live pilot in 2023 with University College London Hospitals and AstraZeneca, transferring more than 6,600 data points from UCLH's Epic EHR system into a copy of a Phase III oncology trial database, successfully mapping 100 percent of targeted vital signs and labs data. IgniteData has since gone live with Archer at Royal Berkshire NHS Foundation Trust, using SMART on FHIR technology to eliminate manual data entry for clinical research staff. The company has secured more than £1 million in UK government Innovate UK funding alongside an $8 million seed investment round to scale the platform.

OpenClinica

OpenClinica was the world's first commercial open-source clinical trial software for electronic data capture, and the company's EHR-to-EDC eSource solution, Unite, now automates source data acquisition from patient medical records into clinical trial databases across a network of more than 450 clinical trial sites. Founded in 2004 and headquartered in Waltham, Massachusetts, the company reports its Unite platform delivers a 61 percent reduction in data collection time compared with sites using manual data abstraction, backed by standards including SMART on FHIR that let sites become operational within hours rather than weeks. OpenClinica's broader open-source EDC platform has more than 1,200 installations worldwide and an active community of more than 18,000 members, with adoption ranging from large pharmaceutical sponsors to research groups in Kenya using the software to manage multi-site African trials. CEO Cal Collins has represented the company at industry webinars discussing real-world experience with EHR eSource alongside partners including UC San Diego Health and Quantum Leap Healthcare Collaborative.

Triomics

Triomics built OncoLLM, a generative AI model specifically trained on oncology data, to interpret the roughly 80 percent of a patient's electronic health record that exists as unstructured text, such as physician notes and PDFs, and automatically match patients to relevant clinical trials. Founded in 2020 by CEO Sarim Khan, a former MIT biotech researcher, and CTO Hrituraj Singh, a former Adobe AI researcher, the company raised a $15 million Series A round in 2024 from investors including Lightspeed, General Catalyst, and Y Combinator. In late 2025, Memorial Sloan Kettering Cancer Center began deploying Triomics' AI-powered clinical trial matching and screening platform across its trial portfolio, following the company's participation in MSK's iHub Challenge program. The company reports that manual chart review for trial matching can take up to 45 minutes per patient, a bottleneck its platform is built to eliminate by pre-screening every patient visit against a site's active trials automatically.

Yonalink

Yonalink offers an EHR-to-EDC streaming platform that extracts up-to-date patient data from any electronic health record system and streams it in real time into a clinical trial's electronic data capture system, using AI-driven mapping to convert unstandardized data into SDTM-compliant case report form fields. Headquartered in Boston with R&D operations in Israel, the company raised a $6 million seed round led by the Debiopharm Innovation Fund in 2022 to scale its platform globally. In 2023, Hadassah Medical Organization in Jerusalem, which initiates close to 500 new clinical trials annually, adopted Yonalink's platform to stream real-time patient data from its EHR systems into clinical trial databases. Yonalink completed what it describes as the largest EHR-to-EDC live pilot study in the industry in 2024, streaming data across 21 medical centers in the US and Israel with 93 percent of requested data transferred at 100 percent accuracy.

Explore the full eHealth Records to EDC Connector Apps landscape

The companies above represent a portion of a much larger field.

Diligent's platform includes over 65 eHealth Records to EDC Connector App Vendors, many with Vendor qualification data available on demand. Book a demo to explore Diligent's full vendor discovery database.

This article is intended as an informational overview of vendors operating in this space. Inclusion on this list does not constitute an endorsement, recommendation, or qualification by Diligent.